Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes

Summary: Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a).This mark has been reported to associate with silent genes.Here, we use a cell model of neural differentiation, which upon PRMT6 knockout exhibits proliferation and differentiation defects.Strikingly, we detect PRMT6-depen

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